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This condition affects different population groups ranging from a low of 0.7% to a high of 81%.1 In the general population, the mean value of chronic constipation prevalence including patient-reported or based on various existing definition criteria is estimated at 12% to 30% of the population,1–4 and for its subtype functional constipation, it is 4.6% to 17%.2,5 Although functional constipation prevalence has not been globally investigated in Iran, recently in Kerman, the biggest city in the Southeast of Iran, it has been estimated at over 9.4%.6 Functional constipation is a heterogeneous condition that, beyond generally decreased frequency of defecation, includes a diversity of symptoms such as bloating, straining, abdominal pain, a feeling of incomplete evacuation, and hard or lumpy stools.7 Despite constipation not being a life-threatening condition, because of its negative effect on patients’ quality of life that subsequently leads to great economic consequences,1 its treatment is considered very important by health providers. Forty-two patients enrolled in the study with confirmed functional constipation from the Department of Gastroenterology in Shariati Hospital and Shariatpanahi Iranian Traditional Medicine Clinic. All authors edited and approved the final version of the article. The frequency of side effects was similar after three months. So we decided to use the items of the PAC-SYM questionnaire to evaluate patients’ constipation-related symptoms. Composition of Descurainia sophia and its biological activity 59 Chinese herb medicinal raw materials [3]. The primary end point was the proportion of patients achieving ≥3 complete spontaneous bowel movements per week. Patients’ satisfaction score and physician’ satisfaction score in visual analogue scale were both >66 mm (Table 3). The trial was conducted in compliance with Declaration of Helsinki Good Clinical Practice guidelines at the Department of Gastroenterology in Shariati Hospital and Shariatpanahi Iranian Traditional Medicine Clinic in Tehran. Some medical use of D. sophia extracts include treatment Similar to a validated original questionnaire we designed a checklist with abdominal, stool, and rectal symptoms subscales. Rich TCG. Contact us if you experience any difficulty logging in. Jap… Descurainia sophia L. known commonly as flixweed acts as first-line medical treatment for constipation in Iranian traditional medicine. The juice of the plant has been used in the treatment of chronic coughs, hoarseness and ulcerated sore throats. Chronic constipation is a very common gastrointestinal problem with minimal data available about its true epidemiology. Journal of Evidence-Based Complementary & Alte... Categorization of Functional Constipation in Traditional Persian Medicine: A Descriptive Study. The e-mail addresses that you supply to use this service will not be used for any other purpose without your consent. Dizziness. Chronic constipation is a common gastrointestinal disorder that effects an estimated 12% to 30% of general population worldwide. The mean drug intake that improved patients’ bowel habits was 39.33 mL (equivalent to 28.9 g) by the measure. glabrata N.Busch Descurainia sophia var. A still valid help in medical practice and clinical research, Frontiers in Cellular and Infection Microbiology, SAGE Publications Inc unless otherwise noted. The overall and subscale score changes are illustrated in Table 2. No statistically significant difference was found between the efficacy of both interventions in the treatment of constipation at the end of the third and eighth weeks of intervention. So we could not answer the question if benefits of this plant would be maintained with longer treatment. For more information view the SAGE Journals Sharing page. We undertook this study to assess the epigenetic effects of ethanol extract of D. sophia seeds (DSE) in an ovalbumin (OVA)-induced mouse model of asthma. Camilleri, M, Kerstens, R, Rykx, A, Vandeplassche, L. Quigley, E, Vandeplassche, L, Kerstens, R, Ausma, J. Descurainia pinnata: siliques clavate or subclavate in outline, 1-2 mm wide, rounded to obtuse at the apex, and leaf blades usually stipitate glandular (vs. D. sophia, with siliques narrow-linear in outline, mostly 0.5-0.8 mm wide, and leaf blades usually eglandular). It has also healing effect on wounds and injuries [23] and bedsores [22], removed uterine discharges [23], facilitated childbirth [32], and has demonstrated inhibitory effects on … Hashem Dabaghian, F, Taghavi Shirazi, M, Amini Behbahani, F, Shojaee, A. Zarshenas, MM, Petramfar, P, Firoozabadi, A, Moein, MR, Mohagheghzadeh, A. Pasalar, M, Bagheri Lankarani, K, Mehrabani, D, Tolidei, H, Naseri, M. Frank, L, Kleinman, L, Farup, C, Taylor, L, Miner, P. Cohen, J . The email address and/or password entered does not match our records, please check and try again. Thirty-five patients completed the program with no important adverse effect. The sample passed all the necessary laboratory items according to the Iran Herbal Pharmacopeia and the World Health Organization. These changes were 0.94, 0.61, 0.64, and 1.37 in total, abdominal, rectal, and stool PAC-SYM items scores, respectively (P < .001 by paired t test). So we decided to use the items of the PAC-SYM questionnaire to evaluate patients’ constipation-related symptoms. It seems that D. sophia L. can modify the digestion process and patients can excrete large amounts of the substance that causes warts.Therefore, it is better to use it more than 40 days. Descurainia sophia seeds produce mucilage when wetted. Patients’ Demographics and Constipation Characteristic Data. Recent data have shown that stool form scales, especially Bristol Stool Form Scale, are responsive to changes in gut transit time and can be used with certainty to monitor motility changes in intestinal function.34 In this research, only 14.3% of patients had a normal type of Bristol Stool Form Scale (type 3 or 4); a high percentage of them, 74.3% of the patients, achieved the normal type of stool form at the end of program. Objective . The present study investigated the inhibitory effects of an ethanol extract of D. sophia seeds (EEDS) on human Phase I/II (DMEs) and P-glycoprotein (p-gp) in vitro. Then the seeds were filled into plastic boxes and with a measure were offered to the cooperative patients. Also Descurainia sophia was well tolerated. effects of Descurainia sophia on small cell carcinoma of the lung [28,29], colon cancer [30], and glioma [31] have been proved. A total of 28.6% of the patients did not have any CSBMs/week and 54.4% had ≥3 CSBMs/week (data not provided). Canadian Journal of Plant Science. "Roadsides, waste places, disturbed sites, railroad embankments, hillsides, mountain slopes, canyon bottoms, stream banks, fields, lawns, pastures, deserts, sagebrush and pinyon-juniper communities; 0 … So, in conclusion, Descurainia sophia is safe and effective in the treatment of chronic functional constipation. Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. The primary end point was the proportion of patients achieving ≥3 complete spontaneous bowel movements per week. Globally, Descurainia sophia had a large effect on overall symptoms (1.61; Table 3). Finland: litutilli. We monitored and recorded all adverse events. Gong et al . AG drafted the first version. Then the seeds were filled into plastic boxes and with a measure were offered to the cooperative patients. Ethical ApprovalThe protocol of this trial was approved by Office of Research Affairs, Deputy of Research and Technology, Shahid Beheshti University of Medical Sciences (Reference Number: 150). The mean numbers of laxatives/week used by patients, before and after 4 weeks treatment, are displayed in Table 3 (2.89 and 0.09, respectively, P = .002 by Wilcoxon signed-rank test). In this study, protective effects of … The seeds of Descurainia sophia are traditionally used to treat coughs, asthma and edema, but their effects on asthma have not been investigated by multi-omics analysis. 3, May-Jun 2016 267 inflammatory as well as antipyretic effects have been experimentally assessed. Descurainia sophia Photo courtesy Debra L. Cook. If the dose of drug was not sufficient to generate complete bowel movement, they were recommended to increase the Descurainia sophia dose every 3 days to reach a satisfactory level. We calculated body mass index using the followed equitation: body mass index = weight (kg)/(height (m2))2 and categorized them according to the World Health Organization body mass index principal cutoff points.22 Although current cutoff points of overweightness and obesity may be not suitable in the Persian population,23 as it is not in many Asian populations,24 with regard to minimal data about the suitable cutoff points for Iranian population, we decided to use aforementioned points as a general standard. Pare, P, Ferrazzi, S, Thompson, W, Irvine, E, Rance, L. Garrigues, V, Gálvez, C, Ortiz, V, Ponce, M, Nos, P, Ponce, J. Zahedi, MJ, Moghadam, SD, Abbasi, MHB, Mirzaei, SMS. It seems that Descurainia sophia oil, as an East Asian folk herbal drug, can suppress the methamphetamine-induced cell death. All authors edited and approved the final version of the article. 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