The combination of 0.25 mg minoxidil and 25 mg of spironolactone may prove to be the best option as the low dose of OM limits side effects while spironolactone aids in reducing fluid/sodium retention properties of minoxidil. Low-dose oral minoxidil (0.25mg daily) has been successfully used in combination with spironolactone in the treatment of female pattern hair loss (FPHL) 1.Oral minoxidil (5mg daily) has been shown to be efficacious in male pattern hair loss (MPHL) 2,3.The objective of our study was to evaluate the efficacy and safety of low-dose sublingual minoxidil (0.45mg daily) in MPHL and FPHL. 2019 Feb;20(1):147-153. doi: 10.1007/s40257-018-0387-0. Learn about drug interactions between spironolactone oral and minoxidil oral and use the RxList drug interaction checker to check drug combinations. Indian Dermatol Online J. 2012. Most women affected by the condition start with slightly increased hair shedding. 2020 Jun;6(3):175-176. doi: 10.1159/000505820. Minoxidil use in dermatology, side effects and recent patents. Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study. Over time, the patient notices decreased hair density and a more see through appearance to the scalp. Side effects were seen in eight women but were generally mild. Dermatol Ther (Heidelb). Background: Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. 2007 Feb;48(1):43-5. doi: 10.1111/j.1440-0960.2007.00332.x. HHS Prescribing Habits for Androgenic Alopecia among Dermatologists in Spain in 2019-2020: A Cross-Sectional Study. Referencias bibliográficas: SINCLAIR RD. Together, these studies speak to a relatively good safety profile of oral minoxidil. 0 comments. 2. The children subsequently developed a condition called “werewolf syndrome” in which large parts of their bodies become covered in hair.  |  The most common side effects is the increased hair on the face (especially upper lip) and body that some patients get. Case series of oral minoxidil for androgenetic and traction alopecia: Tolerability & the five C’s of oral therapy. No patients developed hyperkalemia or any other blood test abnormality. Background: Mean age was 48.44 years (range 18-80).  |  The subject was initially treated with a 200 mg oral dose of spironolactone daily. Australas J Dermatol. The dose of minoxidil prescribed was 0.25 mg and the dose of spironolactone used was 25 mg. 100 women were included in this study. Clipboard, Search History, and several other advanced features are temporarily unavailable. Introduction. Minoxidil and its use in hair disorders: a review. Prospective, uncontrolled, open-label observational study. HealthDay News — Once-daily capsules containing a combination of minoxidil and spironolactone appear to be safe and effective for the treatment of … 3 The use of topical minoxidil together with an oral antiandrogen might have an additive effect; however, combination therapy has not been previously reported. Antiandrogen therapy with either spironolactone or cyproterone acetate is commonly used to treat FPHL, as is topical minoxidil. Overall the drug combination reduced shedding and reduced hair loss. In fact, it was Dr Sinclair who showed this many years ago as well. Int J Dermatol. Background. Discussion: To report on a case series of women with pattern hair loss (PHL) treated with once daily minoxidil 0.25 mg and spironolactone 25 mg. Treatment of female pattern hair loss with a combination of spironolactone and minoxidil. 2020 Sep;6(5):283-286. doi: 10.1159/000509063. Background: Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. Minoxidil (Rogaine) and spironolactone are used widely by women with hair loss to slow shedding and induce growth. Recent Pat Inflamm Allergy Drug Discov. Please enable it to take advantage of the complete set of features! It is known to increase hair growth on the body as a side effects. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Note Spironolactone and Minoxidil should never be combined in the same lotion due to instability issues. Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. F1000Res. Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. 2 The mechanism of action of minoxidil is unknown, but does not involve androgen pathways. Forty women received spironolactone 200 mg daily and 40 women received cyproterone acetate, either 50 mg daily or 100 mg for 10 days per month if premenopausal. Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. All photos and information in this website is copyrighted unless otherwise stated. Mean duration of diagnosis was 6.5 years (range 0.5-30). Dermatol Ther . The ease of taking oral minoxidil vs topical minoxidil does make it a important option for further study. Its use in hair loss is entirely off label. © 2017 The International Society of Dermatology. HOME        RESEARCH     BIO - DR. DONOVAN     DAILY BLOG     CONTACT US, 4370 Lorimer Road, Suite 334B Whistler, BC, Canada (604) 283-1887. NLM 1. 1) Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. Both minoxidil and spironolactone were actually first utilized to treat hypertension. Oral minoxidil has been around for many decades and was originally used as a blood pressure medication. - BEGIN YOUR TELEMEDICINE CONSULT NOW, PLANNING YOUR FIRST VISIT WITH DR. DONOVAN, FREQUENTLY ASKED QUESTIONS ABOUT THE FIRST VISIT, FREQUENTLY ASKED QUESTIONS ABOUT SUBSEQUENT APPOINTMENTS, INFORMATION ON FOLLOW UP APPOINTMENT FREQUENCY, SEND US DOCUMENTS AND PHOTOS (SECURE UPLOAD LINK), Referral Information & Form for Physicians, Dr. Donovan's Hair Loss Articles (2011-2020), Combining Oral Minoxidil and Oral Spironolactone for FPHL. When taken separately, each of … Has anyone had any experience with this? Int J Dermatol. Epub 2020 Jul 20. (Nobody in the world has more experience with oral minoxidil for hair loss than Dr. Sinclair). 2012 May;6(2):130-6. doi: 10.2174/187221312800166859. It was at this point in the study that a twice daily dose of minoxidil 5% solution was prescribed, and further hair regrowth was documented. How long before you saw results and have you had any side effects. And alternative options – such as scalp massage and microneedling – also exist. Mean change in blood pressure was -4.52 mmHg systolic and -6.48 mmHg diastolic. Rodney D. Sinclair, Female pattern hair loss: a pilot study investigating combination therapy with low‐dose oral minoxidil and spironolactone, International Journal of Dermatology, 10.1111/ijd.13838, 57, 1, (104-109), (2017). Women newly diagnosed with a Sinclair stage 2-5 PHL were scored for hair shedding and hair density before and after 12 months of treatment with oral minoxidil 0.25 mg and spironolactone 25 mg. Oral minoxidil is not FDA approved for hair loss. The mean age was 48.44 years and the mean duration of diagnosis was 6.5 years. Only 2 % of patients dropped out of the study. Objective. Low-Dose Oral Minoxidil for Female Pattern Hair Loss: A Unicenter Descriptive Study of 148 Women. I think minoxidil is a very specialist product and if you were to stop oral minoxidil some hairs would be lost unless you replaced with something similar i.e topical minoxidil. Many patients give up after a period of time. It should not be considered a substitute for professional medical advice. eCollection 2019. 2019 Aug 9;13:2777-2786. doi: 10.2147/DDDT.S214907. Oral Minoxidil . Female Pattern Hair Loss (FPHL), also known as female hair thinning or female androgenetic alopecia is a common type of hair loss that affects about one-third of women. Suchonwanit P, Iamsumang W, Rojhirunsakool S. Am J Clin Dermatol. Minoxidil Topical rated 5.5/10 vs Spironolactone rated 7.3/10 in overall patient satisfaction. But i did not lose much if any ground switching from Oral spironolactone to topical RU after a few years because they have similar modes of action.  |  This is an interesting study. Website Disclaimer, Scarring Alopecia - Frequently Asked Questions, Alopecia areata - Frequently Asked Questions, Our International Hair Loss Course for Physicians, APPOINTMENT TODAY? 2020 Jul 13;11(4):493-501. doi: 10.4103/idoj.IDOJ_334_19. It has long been known that the combination of topical minoxidil and oral spirionlactone (at higher does) are beneficial to FPHL. Mean hair shedding score at baseline was 4.82. Spironolactone is androgen dependent and has been approved for treating high blood pressure, but is not commercially available for hair loss. eCollection 2017. 2017 Sep 6;6:1650. doi: 10.12688/f1000research.11775.1. eCollection 2020 Jul-Aug. Rodrigues-Barata R, Moreno-Arrones OM, Saceda-Corralo D, Jiménez-Cauhé J, Ortega-Quijano D, Fernández-Nieto D, Jaén-Olasolo P, Vaño-Galvan S. Skin Appendage Disord. All causes of hyperandrogenism, such as ovarian or adrenal tumours, polycystic ovarian syndrome and adrenal hyperplasia, can induce rapid hair loss in women. 8) Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. 2018. Application of minoxidil does have it's own unique set of challenges. Sinclair RD, International Journal of Dermatol, 2018, Jan;57 (1): 104-108. Rod Sinclair from Australia set out to study the potential benefits of using oral minoxidil and oral spironolactone together. The ease of taking oral minoxidil vs topical minoxidil does make it a important option for further study. 2018; JIMENEZ J., SACEDA CORRALO D. RODRIGUEZ BARATA R., VAÑÓ-GALVAN S. Effectiveness and safety of low-dose oral minoxidil in male androgenetic alopecia.JAAD , 2019 , May. Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. The diagnosis of FPHL is associated with underlying hypertension in women aged £35 years and coronary artery disease in women aged £50 years.7 One study found that patterned hair loss was an in… NIH Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. Only 2 of the 100 patients overall discontinued treatment and these were patients with hives (urticaria). See Article “The Top 10 Things You need to Know About Oral Minoxidil”. Placebo-controlled studies to investigate this further are warranted. This site needs JavaScript to work properly. Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment. If you are going to use or prescribe oral minoxidil, you need to know a thing or two (or three) about it - … Oral Minoxidil Excessive Body Hair Increase Side Effect. Dizziness, headaches, hives, ankle swelling are among the other side effects. Epub 2017 Dec 12. But when it comes right down to it, the fact of the matter is you need to treat the underlying cause of your condition if you want to stop hair loss and perhaps even regrow your hair. 2018 Jan;57(1):104-109. doi: 10.1111/ijd.13838. Objective: J. Dermatol. It was discovered that patients taking these drugs were … In another study by Dr. Sinclair (of chronic telogen effluvium) which also involved study of oral minoxidil, there were no drop outs. USA.gov. Compare Minoxidil Topical vs Spironolactone head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Sinclair RD. Our Laboratory also produces a prescription range of hair lotions which can include Minoxidil, Retinoic acid, finasteride, progesterone and spironolactone. Topical Minoxidil remains the only formally FDA and Health Canada approved treatment for FPHL. 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